dc.contributor.author | Pedersen, Hilde Røgeberg | |
dc.contributor.author | Gilson, Stuart | |
dc.contributor.author | Landsend, Erlend Christoffer Sommer | |
dc.contributor.author | Utheim, Øygunn Aass | |
dc.contributor.author | Utheim, Tor Paaske | |
dc.contributor.author | Baraas, Rigmor C. | |
dc.date.accessioned | 2024-08-15T12:27:43Z | |
dc.date.available | 2024-08-15T12:27:43Z | |
dc.date.created | 2023-05-02T14:31:13Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Pedersen, H. R., Gilson, S. J., Landsend, E. C. S., Utheim, Ø. A., Utheim, T. P., & Baraas, R. C. (2023). Rod and Cone Dark Adaptation in Congenital Aniridia and Its Association With Retinal Structure. Investigative Ophthalmology & Visual Science, 64(4). | en_US |
dc.identifier.issn | 0146-0404 | |
dc.identifier.uri | https://hdl.handle.net/11250/3146591 | |
dc.description.abstract | Purpose: To characterize the association between dark-adapted rod and cone sensitivity and retinal structure in PAX6-related aniridia.
Methods: Dark-adaptation curves were measured after a 5-minute exposure to bright light with red (625 nm) and green (527 nm) 2° circular light stimuli presented at ≈20° temporal retinal eccentricity in 27 participants with aniridia (nine males; 11–66 years old) and 38 age-matched healthy controls. A two-stage exponential model was fitted to each participant's responses to determine their cone and rod thresholds over time. The thicknesses of macular inner and outer retinal layers were obtained from optical coherence tomography images in 20 patients with aniridia and the 38 healthy controls. Aniridia-associated keratopathy (AAK) grade (0–3) and lens opacities were quantified by clinical examination of the anterior segment.
Results: The rod–cone break time was similar between patients with aniridia and healthy controls. Dark-adapted cone and the rod thresholds were higher in aniridia compared with healthy controls. In aniridia, foveal outer retinal layer thickness correlated with both final cone and rod thresholds. A multiple regression model indicated that foveal outer retinal layer thickness and age were the main explanatory variables to predict both final cone and rod thresholds in aniridia when the AAK grade was 2 or less.
Conclusions: The results show that both rod- and cone-related functions are affected in PAX6-related aniridia and suggest that retinal anatomical and physiological changes extend beyond the area commonly studied in this condition: the central macula. | en_US |
dc.language.iso | eng | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Rod and Cone Dark Adaptation in Congenital Aniridia and Its Association With Retinal Structure | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | © 2023 The Authors. | en_US |
dc.source.pagenumber | 1-7 | en_US |
dc.source.volume | 64 | en_US |
dc.source.journal | Investigative Ophthalmology and Visual Science | en_US |
dc.source.issue | 4 | en_US |
dc.identifier.doi | https://doi.org/10.1167/iovs.64.4.18 | |
dc.identifier.cristin | 2144760 | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |