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dc.contributor.authorPedersen, Hilde Røgeberg
dc.contributor.authorGilson, Stuart
dc.contributor.authorLandsend, Erlend Christoffer Sommer
dc.contributor.authorUtheim, Øygunn Aass
dc.contributor.authorUtheim, Tor Paaske
dc.contributor.authorBaraas, Rigmor C.
dc.date.accessioned2024-08-15T12:27:43Z
dc.date.available2024-08-15T12:27:43Z
dc.date.created2023-05-02T14:31:13Z
dc.date.issued2023
dc.identifier.citationPedersen, H. R., Gilson, S. J., Landsend, E. C. S., Utheim, Ø. A., Utheim, T. P., & Baraas, R. C. (2023). Rod and Cone Dark Adaptation in Congenital Aniridia and Its Association With Retinal Structure. Investigative Ophthalmology & Visual Science, 64(4).en_US
dc.identifier.issn0146-0404
dc.identifier.urihttps://hdl.handle.net/11250/3146591
dc.description.abstractPurpose: To characterize the association between dark-adapted rod and cone sensitivity and retinal structure in PAX6-related aniridia. Methods: Dark-adaptation curves were measured after a 5-minute exposure to bright light with red (625 nm) and green (527 nm) 2° circular light stimuli presented at ≈20° temporal retinal eccentricity in 27 participants with aniridia (nine males; 11–66 years old) and 38 age-matched healthy controls. A two-stage exponential model was fitted to each participant's responses to determine their cone and rod thresholds over time. The thicknesses of macular inner and outer retinal layers were obtained from optical coherence tomography images in 20 patients with aniridia and the 38 healthy controls. Aniridia-associated keratopathy (AAK) grade (0–3) and lens opacities were quantified by clinical examination of the anterior segment. Results: The rod–cone break time was similar between patients with aniridia and healthy controls. Dark-adapted cone and the rod thresholds were higher in aniridia compared with healthy controls. In aniridia, foveal outer retinal layer thickness correlated with both final cone and rod thresholds. A multiple regression model indicated that foveal outer retinal layer thickness and age were the main explanatory variables to predict both final cone and rod thresholds in aniridia when the AAK grade was 2 or less. Conclusions: The results show that both rod- and cone-related functions are affected in PAX6-related aniridia and suggest that retinal anatomical and physiological changes extend beyond the area commonly studied in this condition: the central macula.en_US
dc.language.isoengen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleRod and Cone Dark Adaptation in Congenital Aniridia and Its Association With Retinal Structureen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holder© 2023 The Authors.en_US
dc.source.pagenumber1-7en_US
dc.source.volume64en_US
dc.source.journalInvestigative Ophthalmology and Visual Scienceen_US
dc.source.issue4en_US
dc.identifier.doihttps://doi.org/10.1167/iovs.64.4.18
dc.identifier.cristin2144760
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal