dc.contributor.author | Nilsen, Nickolai Godtfred | |
dc.contributor.author | Gilson, Stuart | |
dc.contributor.author | Pedersen, Hilde Røgeberg | |
dc.contributor.author | Hagen, Lene Aarvelta | |
dc.contributor.author | Wildsoet, Christine F. | |
dc.contributor.author | Baraas, Rigmor | |
dc.date.accessioned | 2024-06-05T09:57:14Z | |
dc.date.available | 2024-06-05T09:57:14Z | |
dc.date.created | 2024-01-10T14:31:05Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Nilsen, N. G., Gilson, S. J., Pedersen, H. R., Hagen, L. A., Wildsoet, C. F., & Baraas, R. C. (2024). The effect of topical 1 % atropine on ocular dimensions and diurnal rhythms of the human eye. Vision Research, 214, Artikkel 108341. | en_US |
dc.identifier.issn | 0042-6989 | |
dc.identifier.uri | https://hdl.handle.net/11250/3132652 | |
dc.description.abstract | The effect of topical 1 % atropine on the diurnal rhythms of the human eye was investigated. Participants wore an activity monitor on Days 1–7. A set of measures (epochs) encompassing intraocular pressure (IOP), ocular biometry, and retinal imaging were obtained on Day 7 (baseline), followed by eight epochs on Day 8, and one on Day 9 from both eyes of healthy participants (n = 22, 19–25 years). The sleep time of participants (collected via actigraphy) was used as a reference in scheduling epochs. Topical 1 % atropine was instilled in the dominant eye on Day 8, 2 h after habitual wake time, using the fellow eye as control (paired-eye design). Sinusoids with a 24-h period were fitted to the data, and a non-linear mixed-effects model was used to estimate rhythmic statistics. There were no interocular differences in any of the measured parameters at baseline. Comparing pre- versus post-atropine in treated eyes revealed lower IOP, deeper anterior chamber (ACD), decreased crystalline lens thickness and shorter axial length (AL). The same trends were observed when comparing atropine-treated versus fellow control eyes, except for IOP and AL (no differences). Both atropine-treated and fellow control eyes showed significant diurnal variations in all ocular parameters, with atropine-treated eyes revealing larger AL and retinal thickness amplitudes, smaller vitreous chamber depth (VCD) amplitudes, and a significant phase advancement for ACD and VCD. There were no interocular differences in choroidal thickness rhythms. In conclusion, while ocular diurnal rhythms persisted after instillation of 1 % atropine, many rhythmic parameters were altered. | en_US |
dc.language.iso | eng | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | The effect of topical 1 % atropine on ocular dimensions and diurnal rhythms of the human eye | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | © 2023 The Author(s). | en_US |
dc.source.volume | 214 | en_US |
dc.source.journal | Vision Research | en_US |
dc.identifier.doi | https://doi.org/10.1016/j.visres.2023.108341 | |
dc.identifier.cristin | 2224054 | |
dc.source.articlenumber | 108341 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |