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dc.contributor.authorLandsend, Erlend Christoffer Sommer
dc.contributor.authorPedersen, Hilde Røgeberg
dc.contributor.authorUtheim, Øygunn Aass
dc.contributor.authorRueegg, Corina Silvia
dc.contributor.authorBaraas, Rigmor C.
dc.contributor.authorLagali, Neil
dc.contributor.authorBragadottir, Ragnheidur
dc.contributor.authorMoe, Morten Carsten
dc.contributor.authorUtheim, Tor Paaske
dc.identifier.citationInvestigative Ophthalmology and Visual Science. 2019, 60 (13), 4120-4128.nb_NO
dc.descriptionThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licensenb_NO
dc.description.abstractPurpose: To investigate fundus autofluorescence (FAF) and other fundus manifestations in congenital aniridia. Methods: Fourteen patients with congenital aniridia and 14 age- and sex-matched healthy controls were examined. FAF images were obtained with an ultra-widefield scanning laser ophthalmoscope. FAF intensity was quantified in the macular fovea and in a macular ring surrounding fovea and related to an internal reference within each image. All aniridia patients underwent an ophthalmologic examination, including optical coherence tomography and slit-lamp biomicroscopy. Results: Mean age was 28.4 ± 15.0 years in both the aniridia and control groups. Fovea could be defined by subjective assessment of FAF images in three aniridia patients (21.4%) and in all controls (P = 0.001). Mean ratio between FAF intensity in the macular ring and fovea was 1.01 ± 0.15 in aniridia versus 1.18 ± 0.09 in controls (P = 0.034). In aniridia, presence of foveal hypoplasia evaluated by biomicroscopy correlated with lack of foveal appearance by subjective analyses of FAF images (P = 0.031) and observation of nystagmus (P = 0.009). Conclusions: Aniridia patients present a lower ratio between FAF intensity in the peripheral and central macula than do healthy individuals. Both subjective and objective analyses of FAF images are useful tools in evaluation of foveal hypoplasia in aniridia.nb_NO
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.titleCharacteristics and Utility of Fundus Autofluorescence in Congenital Aniridia Using Scanning Laser Ophthalmoscopynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.rights.holder2019 The Authorsnb_NO
dc.source.journalInvestigative Ophthalmology and Visual Sciencenb_NO
cristin.unitnameInstitutt for optometri, radiografi og lysdesign

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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal