Medisinsk genetikk
Recent Submissions
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Expression of NDRG2 is down-regulated in high-risk adenomas and colorectal carcinoma
(Journal article; Peer reviewed, 2007-10-12)BACKGROUND: It has recently been shown that NDRG2 mRNA is down-regulated or undetectable in several human cancers and cancer cell-lines. Although the function of NDRG2 is unknown, high NDRG2 expression correlates with ... -
Meat, vegetables and genetic polymorphisms and the risk of colorectal carcinomas and adenomas
(Journal article; Peer reviewed, 2007-12-19)BACKGROUND: The risk of sporadic colorectal cancer (CRC) is mainly associated with lifestyle factors, particularly dietary factors. Diets high in red meat and fat and low in fruit and vegetables are associated with an ... -
Effects of polymorphisms in ERCC1, ASE-1 and RAI on the risk of colorectal carcinomas and adenomas: a case control study
(Journal article; Peer reviewed, 2006-07-03)BACKGROUND: The risk of sporadic colorectal cancer is mainly associated with lifestyle factors and may be modulated by several genetic factors of low penetrance. Genetic variants represented by single nucleotide polymorphisms ... -
Increased mRNA expression levels of ERCC1, OGG1 and RAI in colorectal adenomas and carcinomas
(Journal article; Peer reviewed, 2006-08-16)BACKGROUND: The majority of colorectal cancer (CRC) cases develop through the adenoma-carcinoma pathway. If an increase in DNA repair expression is detected in both early adenomas and carcinomas it may indicate that low ... -
Polymorphisms of the XRCC1, XRCC3 and XPD genes and risk of colorectal adenoma and carcinoma, in a Norwegian cohort: a case control study
(Journal article; Peer reviewed, 2006-03-16)BACKGROUND: Genetic polymorphisms in DNA repair genes may influence individual variation in DNA repair capacity, which may be associated with risk of developing cancer. For colorectal cancer the importance of mutations in ... -
GPX Pro198Leu and OGG1 Ser326Cys polymorphisms and risk of development of colorectal adenomas and colorectal cancer
(Journal article; Peer reviewed, 2005)Little is known about genetic risk factors for colorectal cancer. We assessed the association between polymorphisms in two genes involved in DNA repair of oxidative stress, GPX and OGG1, and risk of colorectal carcinoma ... -
The ratio of Matriptase/HAI-1 mRNA is higher in colorectal cancer adenomas and carcinomas than corresponding tissue from control individuals
(Journal article; Peer reviewed, 2006-07-04)BACKGROUND: It has recently been shown that overexpression of the serine protease, matriptase, in transgenic mice causes a dramatically increased frequency of carcinoma formation. Overexpression of HAI-1 and matriptase ... -
Association between cigarette smoking, APC mutations and the risk of developing sporadic colorectal adenomas and carcinomas
(Journal article; Peer reviewed, 2006-03-17)BACKGROUND: The association between colorectal cancer (CRC) and smoking has not been consistent. Incomplete smoking history and association to a specific subset of CRC tumors have been proposed as explanations. The adenomatous ...