Blar i Institutt for natur, helse og miljø på emneord "762"

Viser treff 1-5 av 5

    • GPX Pro198Leu and OGG1 Ser326Cys polymorphisms and risk of development of colorectal adenomas and colorectal cancer 

      Hansen, Rikke; Sæbø, Mona; Skjelbred, Camilla Furu; Nexø, Bjørn Andersen; Hagen, Per Chr.; Bock, Günther; Lothe, Inger Marie Bowitz; Johnson, Egil; Aase, Steinar; Hansteen, Inger-Lise; Vogel, Ulla; Kure, Elin H. (Journal article; Peer reviewed, 2005)
      Little is known about genetic risk factors for colorectal cancer. We assessed the association between polymorphisms in two genes involved in DNA repair of oxidative stress, GPX and OGG1, and risk of colorectal carcinoma ...

    • Increased mRNA expression levels of ERCC1, OGG1 and RAI in colorectal adenomas and carcinomas 

      Sæbø, Mona; Skjelbred, Camilla Furu; Nexø, Bjørn Andersen; Wallin, Håkan; Hansteen, Inger-Lise; Vogel, Ulla; Kure, Elin H. (Journal article; Peer reviewed, 2006-08-16)
      BACKGROUND: The majority of colorectal cancer (CRC) cases develop through the adenoma-carcinoma pathway. If an increase in DNA repair expression is detected in both early adenomas and carcinomas it may indicate that low ...

    • Polymorphisms of the XRCC1, XRCC3 and XPD genes and risk of colorectal adenoma and carcinoma, in a Norwegian cohort: a case control study 

      Skjelbred, Camilla Furu; Sæbø, Mona; Wallin, Håkan; Nexø, Bjørn Andersen; Hagen, Per Chr.; Lothe, Inger Marie Bowitz; Aase, Steinar; Johnson, Egil; Hansteen, Inger-Lise; Vogel, Ulla; Kure, Elin H. (Journal article; Peer reviewed, 2006-03-16)
      BACKGROUND: Genetic polymorphisms in DNA repair genes may influence individual variation in DNA repair capacity, which may be associated with risk of developing cancer. For colorectal cancer the importance of mutations in ...

    • The level of claudin-7 is reduced as an early event in colorectal carcinogenesis 

      Bornholdt, Jette; Friis, Stine; Godiksen, Sine; Poulsen, Steen S.; Santoni-Rugiu, Eric; Bisgaard, Hanne C.; Lothe, Inger Marie Bowitz; Andersen, Tone Ikdahl; Tveit, Magne Kjell; Johnson, Egil; Kure, Elin H.; Vogel, Lotte K. (Journal article; Peer reviewed, 2011-02-10)
      BACKGROUND: Compromised epithelial barriers are found in dysplastic tissue of the gastrointestinal tract. Claudins are transmembrane proteins important for tight junctions. Claudins regulate the paracellular transport and ...

    • The ratio of Matriptase/HAI-1 mRNA is higher in colorectal cancer adenomas and carcinomas than corresponding tissue from control individuals 

      Vogel, Lotte K.; Sæbø, Mona; Skjelbred, Camilla Furu; Abell, Kathrine; Pedersen, Esben D.K.; Vogel, Ulla; Kure, Elin H. (Journal article; Peer reviewed, 2006-07-04)
      BACKGROUND: It has recently been shown that overexpression of the serine protease, matriptase, in transgenic mice causes a dramatically increased frequency of carcinoma formation. Overexpression of HAI-1 and matriptase ...