Now showing items 61-80 of 143

    • Comparison of Intravoxel incoherent motion imaging and multiecho dynamic contrast-based MRI in rectal cancer 

      Bakke, Kine Mari; Grøvik, Endre; Meltzer, Sebastian; Negård, Anne; Holmedal, Stein Harald; Mikalsen, Lars Tore G; Lyckander, Lars Gustav; Ree, Anne Hansen; Gjesdal, Kjell-Inge; Redalen, Kathrine; Bjørnerud, Atle (Journal article; Peer reviewed, 2019)
      Background Dynamic contrast‐based MRI and intravoxel incoherent motion imaging (IVIM) MRI are both methods showing promise as diagnostic and prognostic tools in rectal cancer. Both methods aim at measuring perfusion‐related ...
    • Hyaluronan-Based Hydrogel Scaffolds for Limbal Stem Cell Transplantation: A Review 

      Yazdani, Mazyar; Shahdafar, Aboulghassem; Jackson, Catherine; Utheim, Tor Paaske (Peer reviewed; Journal article, 2019)
      Hyaluronan (HA), also termed hyaluronic acid or hyaluronate, is a major component of the extracellular matrix. This non-sulfated glycosaminoglycan plays a key role in cell proliferation, growth, survival, polarization, and ...
    • Diagnostic Test Efficacy of Meibomian Gland Morphology and Function 

      Xiao, Jiaxin; Adil, Muhammed Yasin; Olafsson, Jonatan; Chen, Xiangjun; Utheim, Øygunn Aass; Ræder, Sten; Lagali, Neil; Dartt, Darlene Ann; Utheim, Tor Paaske (Journal article; Peer reviewed, 2019)
      Meibomian gland dysfunction (MGD) is the leading cause of dry eye and proposed treatments are based on disease severity. Our purpose was to establish reliable morphologic measurements of meibomian glands for evaluating MGD ...
    • The cone photoreceptor mosaic in aniridia: within-family phenotype-genotype discordance 

      Pedersen, Hilde Røgeberg; Neitz, Maureen; Gilson, Stuart; Landsend, Erlend Christoffer Sommer; Utheim, Øygunn Aass; Utheim, Tor Paaske; Baraas, Rigmor C. (Peer reviewed; Journal article, 2019)
      Purpose Investigate in vivo cone photoreceptor structure in familial aniridia caused by deletion in the PAX6 gene to elucidate the complexity of between-individual variation in retinal phenotype. Design Descriptive ...
    • Discomfort glare and psychological stress during computer work: subjective responses and associations between neck pain and trapezius muscle blood flow 

      Mork, Randi; Falkenberg, Helle Kristine; Fostervold, Knut Inge; Thorud, Hanne Mari Schiøtz (Peer reviewed; Journal article, 2019)
      Purpose Exposure to additional environmental stress during computer work, such as visual and psychological demands, is associated with increased eye and neck discomfort, altered moods, and reduced well-being. The aim of ...
    • The Glutamine Transporter Slc38a1 Regulates GABAergic Neurotransmission and Synaptic Plasticity 

      Raheel, Tayyaba Qureshi; Sørensen, Christina; Berghuis, Paul; Jensen, Vidar; Dobszay, Marton B.; Farkas, Tamas; Dalen, Knut Tomas; Guo, Caiying; Hassel, Bjørnar; Utheim, Tor Paaske; Hvalby, Øivind C; Hafting, Torkel; Harkany, Tibor; Fyhn, Marianne; Chaudhry, Farrukh Abbas (Journal article; Peer reviewed, 2019)
      GABA signaling sustains fundamental brain functions, from nervous system development to the synchronization of population activity and synaptic plasticity. Despite these pivotal features, molecular determinants underscoring ...
    • Single-cone imaging in inherited and acquired colour vision deficiencies 

      Baraas, Rigmor C.; Pedersen, Hilde Røgeberg; Hagen, Lene Aarvelta (Journal article; Peer reviewed, 2019)
      Colour vision deficiencies are common in humans and occur both as a consequence of inherited cone opsin mutations, altering the number or function of the different cone types expressed in the retina, and acquired through ...
    • Utility of Tear Osmolarity Measurement in Diagnosis of Dry Eye Disease 

      Tashbayev, Behzod; Utheim, Tor Paaske; Utheim, Øygunn Aass; Ræder, Sten; Jensen, Janicke Cecilie Liaaen; Yazdani, Mazyar; Lagali, Neil Satish; Vitelli, Valeria; Dartt, Darlene Ann; Chen, Xiangjun (Peer reviewed; Journal article, 2020)
      The prevalence of dry eye disease is high worldwide and poses a great burden on patients’ daily lives. Accurate diagnosis of the disease is important, and it requires application of various methods. Hyperosmolarity is ...
    • Cognitive and sensorimotor function in participants being treated for trigeminal neuralgia pain 

      Coats, Rachel O.; Crossley, Kirsty L.; Conlin, Naomi; Wu, Jianhua; Zakrzewska, Joanna M.; Pavitt, Sue H.; Phillips, Nicholas; Mon-Williams, Mark (Peer reviewed; Journal article, 2020)
      Background: Trigeminal neuralgia (TN) is an orofacial condition defined by reoccurring, spontaneous, short-lived but excruciating stabbing pain. Pharmacological interventions constitute the first-line treatment for TN, ...
    • Headache, eyestrain, and musculoskeletal symptoms in relation to smartphone and tablet use in healthy adolescents. 

      Falkenberg, Helle Kristine; Johansen, Tina Regine; Thorud, Hanne Mari Schiøtz (Peer reviewed; Journal article, 2020)
      Neck pain and headache are leading causes of years lived with disability globally, and the prevalence is gradually increasing from school age to early adulthood. These symptoms have been linked to the use of digital devices. ...
    • Ethics and the marketing authorization of pharmaceuticals: what happens to ethical issues discovered post-trial and pre-marketing authorization? 

      Bernabe, Rosemarie de la Cruz; van Thiel, Ghislaine J.M.W.; Breekveldt, Nancy S.; Gispen, Christine C.; van Delden, Johannes J.M. (Peer reviewed; Journal article, 2020)
      Background: In the EU, clinical assessors, rapporteurs and the Committee for Medicinal Products for Human Use are obliged to assess the ethical aspects of a clinical development program and include major ethical flaws in ...
    • Developing and Implementing a School-led Motor Intervention for Children with Handwriting Difficulties 

      Shire, Katy A.; Atkinson, Jo; Williams, Emily A.; Pickavance, John; Magallón, Sara; Hill, Liam J. B.; Waterman, Amanda H.; Sugden, David A.; Mon-Williams, Mark (Peer reviewed; Journal article, 2020)
      We describe the development of an evidence-based motor intervention and an implementation pilot study in ten primary schools, involving 515 children (4–11 years). ‘Helping Handwriting SHINE’ (HHS) is a novel, school-led, ...
    • Sex differences and tumor blood flow from dynamic susceptibility contrast MRI are associated with treatment response after chemoradiation and long-term survival in rectal cancer 

      Bakke, Kine Mari; Meltzer, Sebastian; Grøvik, Endre; Negård, Anne; Holmedal, Stein Harald; Gjesdal, Kjell-Inge; Bjørnerud, Atle; Ree, Anne Hansen; Redalen, Kathrine (Peer reviewed; Journal article, 2020)
      Sex differences, tumor vascularity, and blood flow seen on multiecho dynamic contrast–based MRI scans enabled prediction of treatment response and overall survival in patients with rectal cancer. Background: MRI is the ...
    • Prevalence of signs and symptoms of dry eye disease 5 to 15 after refractive surgery 

      Gjerdrum, Bjørn; Gundersen, Kjell Gunnar; Lundmark, Per; Potvin, Rick; Aakre, Bente Monica (Peer reviewed; Journal article, 2020)
      Purpose: To compare the prevalence of dry eye disease (DED) as determined by signs and symptoms in patients with a history of laser vision correction (LVC) or implantable collamer lens (ICL) implantation 5–15 years ago ...
    • Exploring sensorimotor performance and user experience within a virtual reality golf putting simulator 

      Harris, David J.; Buckingham, Gavin; Wilson, Mark Robert; Brookes, Jack; Mushtaq, Faisal; Mon-Williams, Mark; Vine, Samuel J. (Peer reviewed; Journal article, 2020)
      In light of recent advances in technology, there has been growing interest in virtual reality (VR) simulations for training purposes in a range of high-performance environments, from sport to nuclear decommissioning. For ...
    • Nursing staff’s evaluation of facilitators and barriers during implementation of wireless nurse call systems in residential care facilities. A cross-sectional study 

      Dugstad, Janne H.; Sundling, Vibeke; Nilsen, Etty; Eide, Hilde (Peer reviewed; Journal article, 2020)
      Background Traditional nurse call systems used in residential care facilities rely on patients to summon assistance for routine or emergency needs. Wireless nurse call systems (WNCS) offer new affordances for persons ...
    • PAX6 Genotypic and Retinal Phenotypic Characterization in Congenital Aniridia 

      Pedersen, Hilde Røgeberg; Baraas, Rigmor C.; Landsend, Erlend Christoffer Sommer; Utheim, Øygunn Aass; Utheim, Tor Paaske; Gilson, Stuart; Neitz, Maureen (Peer reviewed; Journal article, 2020)
      PURPOSE: To investigate the association between PAX6 genotype and macular morphology in congenital aniridia. METHODS: The study included 37 participants (15 males) with congenital aniridia (aged 10–72 years) and 58 ...
    • Emotional communication in home care: A comparison between Norway and Sweden 

      Sundling, Vibeke; Hafskjold, Linda; Eklund, Jakob Håkansson; Holmström, Inger K.; Höglander, Jessica; Sundler, Annelie J.; van Dulmen, Sandra; Eide, Hilde (Peer reviewed; Journal article, 2020)
      Objective: Given the free movement of workers across countries, knowledge regarding communication differences between countries is imperative. In this study, we explored and compared the supportive responses of nursing ...
    • Stem cell function is conserved during shortterm storage of cultured epidermal cell sheets at 12°C 

      Ringstad, Håkon; Reppe, Sjur; Schøyen, Tine Hiorth; Tønseth, Kim Alexander; Utheim, Tor Paaske; Jackson, Catherine (Peer reviewed; Journal article, 2020)
      Transplantation of cultured epidermal cell sheets (CES) can be life-saving for patients with large area burns. CES have also been successfully used to regenerate eye and urethral epithelia in animal models. Short-term ...
    • Nyanser av mørke 

      Wåseth, Helga Iselin (Peer reviewed; Journal article, 2020)
      Studier viser at gatebelysning kan ha negative effekter på naturmangfold og at lysforurensing er et stadig økende problem med varierende konsekvenser for naturen. Samtidig etterspør mange mer belysning for å sikre ...