Blar i Medisinsk genetikk på emneord "Genetics"

Viser treff 1-6 av 6

    • Association between cigarette smoking, APC mutations and the risk of developing sporadic colorectal adenomas and carcinomas 

      Sæbø, Mona; Skjelbred, Camilla Furu; Breistein, Rebecca; Lothe, Inger Marie Bowitz; Hagen, Per Chr.; Bock, Günther; Hansteen, Inger-Lise; Kure, Elin H. (Journal article; Peer reviewed, 2006-03-17)
      BACKGROUND: The association between colorectal cancer (CRC) and smoking has not been consistent. Incomplete smoking history and association to a specific subset of CRC tumors have been proposed as explanations. The adenomatous ...

    • Effects of polymorphisms in ERCC1, ASE-1 and RAI on the risk of colorectal carcinomas and adenomas: a case control study 

      Skjelbred, Camilla Furu; Sæbø, Mona; Nexø, Bjørn Andersen; Wallin, Håkan; Hansteen, Inger-Lise; Vogel, Ulla; Kure, Elin H. (Journal article; Peer reviewed, 2006-07-03)
      BACKGROUND: The risk of sporadic colorectal cancer is mainly associated with lifestyle factors and may be modulated by several genetic factors of low penetrance. Genetic variants represented by single nucleotide polymorphisms ...

    • Expression of NDRG2 is down-regulated in high-risk adenomas and colorectal carcinoma 

      Lorentzen, Anders; Vogel, Lotte K.; Lewinsky, Rikke H.; Sæbø, Mona; Skjelbred, Camilla Furu; Godiksen, Sine; Hoff, Geir; Lothe, Inger Marie Bowitz; Ikdahl, Tone; Kure, Elin H.; Mitchelmore, Cathy (Journal article; Peer reviewed, 2007-10-12)
      BACKGROUND: It has recently been shown that NDRG2 mRNA is down-regulated or undetectable in several human cancers and cancer cell-lines. Although the function of NDRG2 is unknown, high NDRG2 expression correlates with ...

    • Increased mRNA expression levels of ERCC1, OGG1 and RAI in colorectal adenomas and carcinomas 

      Sæbø, Mona; Skjelbred, Camilla Furu; Nexø, Bjørn Andersen; Wallin, Håkan; Hansteen, Inger-Lise; Vogel, Ulla; Kure, Elin H. (Journal article; Peer reviewed, 2006-08-16)
      BACKGROUND: The majority of colorectal cancer (CRC) cases develop through the adenoma-carcinoma pathway. If an increase in DNA repair expression is detected in both early adenomas and carcinomas it may indicate that low ...

    • Meat, vegetables and genetic polymorphisms and the risk of colorectal carcinomas and adenomas 

      Skjelbred, Camilla Furu; Sæbø, Mona; Hjartåker, Anette; Grotmol, Tom; Hansteen, Inger-Lise; Tveit, Kjell M.; Hoff, Geir; Kure, Elin H. (Journal article; Peer reviewed, 2007-12-19)
      BACKGROUND: The risk of sporadic colorectal cancer (CRC) is mainly associated with lifestyle factors, particularly dietary factors. Diets high in red meat and fat and low in fruit and vegetables are associated with an ...

    • Polymorphisms of the XRCC1, XRCC3 and XPD genes and risk of colorectal adenoma and carcinoma, in a Norwegian cohort: a case control study 

      Skjelbred, Camilla Furu; Sæbø, Mona; Wallin, Håkan; Nexø, Bjørn Andersen; Hagen, Per Chr.; Lothe, Inger Marie Bowitz; Aase, Steinar; Johnson, Egil; Hansteen, Inger-Lise; Vogel, Ulla; Kure, Elin H. (Journal article; Peer reviewed, 2006-03-16)
      BACKGROUND: Genetic polymorphisms in DNA repair genes may influence individual variation in DNA repair capacity, which may be associated with risk of developing cancer. For colorectal cancer the importance of mutations in ...