Blar i Medisinsk genetikk på forfatter "Lothe, Inger Marie Bowitz"

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    • Association between cigarette smoking, APC mutations and the risk of developing sporadic colorectal adenomas and carcinomas 

      Sæbø, Mona; Skjelbred, Camilla Furu; Breistein, Rebecca; Lothe, Inger Marie Bowitz; Hagen, Per Chr.; Bock, Günther; Hansteen, Inger-Lise; Kure, Elin H. (Journal article; Peer reviewed, 2006-03-17)
      BACKGROUND: The association between colorectal cancer (CRC) and smoking has not been consistent. Incomplete smoking history and association to a specific subset of CRC tumors have been proposed as explanations. The adenomatous ...

    • Expression of NDRG2 is down-regulated in high-risk adenomas and colorectal carcinoma 

      Lorentzen, Anders; Vogel, Lotte K.; Lewinsky, Rikke H.; Sæbø, Mona; Skjelbred, Camilla Furu; Godiksen, Sine; Hoff, Geir; Lothe, Inger Marie Bowitz; Ikdahl, Tone; Kure, Elin H.; Mitchelmore, Cathy (Journal article; Peer reviewed, 2007-10-12)
      BACKGROUND: It has recently been shown that NDRG2 mRNA is down-regulated or undetectable in several human cancers and cancer cell-lines. Although the function of NDRG2 is unknown, high NDRG2 expression correlates with ...

    • GPX Pro198Leu and OGG1 Ser326Cys polymorphisms and risk of development of colorectal adenomas and colorectal cancer 

      Hansen, Rikke; Sæbø, Mona; Skjelbred, Camilla Furu; Nexø, Bjørn Andersen; Hagen, Per Chr.; Bock, Günther; Lothe, Inger Marie Bowitz; Johnson, Egil; Aase, Steinar; Hansteen, Inger-Lise; Vogel, Ulla; Kure, Elin H. (Journal article; Peer reviewed, 2005)
      Little is known about genetic risk factors for colorectal cancer. We assessed the association between polymorphisms in two genes involved in DNA repair of oxidative stress, GPX and OGG1, and risk of colorectal carcinoma ...

    • Polymorphisms of the XRCC1, XRCC3 and XPD genes and risk of colorectal adenoma and carcinoma, in a Norwegian cohort: a case control study 

      Skjelbred, Camilla Furu; Sæbø, Mona; Wallin, Håkan; Nexø, Bjørn Andersen; Hagen, Per Chr.; Lothe, Inger Marie Bowitz; Aase, Steinar; Johnson, Egil; Hansteen, Inger-Lise; Vogel, Ulla; Kure, Elin H. (Journal article; Peer reviewed, 2006-03-16)
      BACKGROUND: Genetic polymorphisms in DNA repair genes may influence individual variation in DNA repair capacity, which may be associated with risk of developing cancer. For colorectal cancer the importance of mutations in ...