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dc.contributor.authorØyri, Linn Kristin Lie
dc.contributor.authorBogsrud, Martin Prøven
dc.contributor.authorKristiansen, Anne Lene
dc.contributor.authorMyhre, Jannicke Borch
dc.contributor.authorAstrup, Helene
dc.contributor.authorRetterstøl, Kjetil
dc.contributor.authorBrekke, Hilde Kristin
dc.contributor.authorRoeters van Lennep, Jeanine E.
dc.contributor.authorAndersen, Lene Frost
dc.contributor.authorHolven, Kirsten Bjørklund
dc.date.accessioned2022-01-27T12:07:50Z
dc.date.available2022-01-27T12:07:50Z
dc.date.created2022-01-09T16:02:24Z
dc.date.issued2021
dc.identifier.citationØyri, L. K. L., Bogsrud, M. P., Kristiansen, A. L., Myhre, J. B., Astrup, H., Retterstøl, K., Brekke, H. K., Roeters van Lennep, J. E., Andersen, L. F. & Holven, K. B. (2021). Cholesterol at ages 6, 12 and 24 months: Tracking and associations with diet and maternal cholesterol in the Infant Cholesterol Study. Atherosclerosis, 326, 11-16.en_US
dc.identifier.issn0021-9150
dc.identifier.urihttps://hdl.handle.net/11250/2887173
dc.description.abstractBackground and aims: There are indications for tracking of circulating total cholesterol concentration (TC) from childhood to later in life. An increased lifelong TC exposure increases the risk of developing atherosclerosis, however little is known about the determinants of TC early in life. We aimed to describe TC in Norwegian offspring aged 6, 12 and 24 months, and to explore if maternal TC, breastfeeding and offspring diet are associated with offspring TC. Methods: In this cross-sectional study, mothers of offspring aged 6 (n = 629), 12 (n = 258) and 24 (n = 263) months completed a questionnaire of the offspring's diet and took home-based dried blood spot samples from themselves and their offspring. The mothers and offspring participating at age 12 months also participated at age 6 months of the offspring. Results: Offspring TC showed a wide range in all three age groups. Twenty one percent of the offspring had TC ≥ 5.1 mmol/l. There was significant tracking of offspring TC from 6 to 12 months of age (r = 0.42, p < 0.001). Maternal and offspring TC was positively associated in all age groups (0.20 ≤ β ≤ 0.40, p < 0.001 for all). Breastfeeding was positively associated with offspring TC at ages 6 and 12 months (0.05 ≤ β ≤ 0.26, 0.001 ≤ p ≤ 0.03), but not at age 24 months. Conclusions: The wide range in TC and probable tracking of TC from infancy to later in life highlights the importance of early identification of children with elevated TC who can benefit from preventive measures.en_US
dc.language.isoengen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleCholesterol at ages 6, 12 and 24 months: Tracking and associations with diet and maternal cholesterol in the Infant Cholesterol Studyen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holder© 2021 The Author(s).en_US
dc.source.pagenumber11-16en_US
dc.source.volume326en_US
dc.source.journalAtherosclerosisen_US
dc.identifier.doihttps://doi.org/10.1016/j.atherosclerosis.2021.04.017
dc.identifier.cristin1977076
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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