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dc.contributor.authorSieben, Angelien
dc.contributor.authorBredie, Sebastian JH
dc.contributor.authorLuijten, JCHBM
dc.contributor.authorvan Laarhoven, Cornelius JHM
dc.contributor.authorvan Dulmen, Sandra
dc.contributor.authorvan Onzenoort, Hein A W
dc.date.accessioned2020-03-17T11:28:41Z
dc.date.available2020-03-17T11:28:41Z
dc.date.created2019-11-07T17:21:19Z
dc.date.issued2019
dc.identifier.citationBMC Medical Research Methodology. 2019, 19 (1), .en_US
dc.identifier.issn1471-2288
dc.identifier.urihttps://hdl.handle.net/11250/2647163
dc.descriptionThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.en_US
dc.description.abstractPoor medication adherence is a major factor in the secondary prevention of cardiovascular diseases (CVD) and contributes to increased morbidity, mortality, and costs. Interventions for improving medication adherence may have limited effects as a consequence of self selection of already highly adherent participants into clinical trials. Methods: In this retrospective cohort study, existing levels of medication adherence were examined in self-decided participants and non-participants prior to inclusion in a randomized controlled study (RCT), evaluating the effect of an intervention to improve adherence. In addition, the non-participants were further divided into ‘responders’ and ‘non responders’. All individuals had manifest cardiovascular disease and completed a questionnaire with baseline characteristics, the Beliefs about Medicines Questionnaire (BMQ) and the Modified Morisky Scale® (MMS®) as part of a regular screening program. A logistic regression was conducted to examine the relationship between study participation willingness, adherence level and the beliefs about medication. Results: According to the MMS® the adherence level was comparable in all groups. In both (non)-participants groups, 36% was classified as high adherent; 46% participants versus 44% non-participants were classified as medium adherent and 19% of the participants versus 20% of the non-participants were low adherent (p = 0.91. The necessity concern differential (NCD) from the BMQ was 3.8 for participants and 3.4 for non-participants (p = 0.32). Conclusion: This study shows that adherence to medication and beliefs about medication do not differ between participants and non-participants before consenting to participate in an RCT. The study design seems not to have led to greater adherence in the study group.en_US
dc.language.isoengen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titlePrior medication adherence of participants and non participants of a randomized controlled trial to improve patient adherence in cardiovascular risk managementen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holder© The Author(s). 2019en_US
dc.source.pagenumber9en_US
dc.source.volume19en_US
dc.source.journalBMC Medical Research Methodologyen_US
dc.source.issue1en_US
dc.identifier.doi10.1186/s12874-019-0743-7
dc.identifier.cristin1745073
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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