• Metabolic reprogramming involving glycolysis in the hibernating brown bear skeletal muscle 

      Chazarin, Blandine; Storey, Kenneth B.; Ziemianin, Anna; Chanon, Stéphanie; Plumel, M.; Chery, Isabelle; Durand, Christine; Evans, Alina; Arnemo, Jon Martin; Zedrosser, Andreas; Swenson, Jon; Gauquelin-Koch, Guillemette; Simon, Chantal; Blanche, Stephane; Lefai, Etienne; Bertile, Fabrice (Journal article; Peer reviewed, 2019)
      Background In mammals, the hibernating state is characterized by biochemical adjustments, which include metabolic rate depression and a shift in the primary fuel oxidized from carbohydrates to lipids. A number of studies ...
    • Proteolysis inhibition by hibernating bear serum leads to increased protein content in human muscle cells 

      Chanon, Stéphanie; Chazarin, Blandine; Toubhans, Benoit; Durand, Christine; Chery, Isabelle; Robert, Maud; Vieille-Marchiset, Aurélie; Swenson, Jon; Zedrosser, Andreas; Evans, Alina; Brunberg, Sven; Arnemo, Jon Martin; Gauquelin-Koch, Guillemette; Storey, Kenneth B.; Simon, Chantal; Blanc, Stéphane; Bertile, Fabrice; Lefai, Etienne (Journal article; Peer reviewed, 2018)
      Muscle atrophy is one of the main characteristics of human ageing and physical inactivity, with resulting adverse health outcomes. To date, there are still no efficient therapeutic strategies for its prevention and/or ...