• Characteristics and Utility of Fundus Autofluorescence in Congenital Aniridia Using Scanning Laser Ophthalmoscopy 

      Landsend, Erlend Christoffer Sommer; Pedersen, Hilde Røgeberg; Utheim, Øygunn Aass; Rueegg, Corina Silvia; Baraas, Rigmor C.; Lagali, Neil; Bragadottir, Ragnheidur; Moe, Morten Carsten; Utheim, Tor Paaske (Journal article; Peer reviewed, 2019)
      Purpose: To investigate fundus autofluorescence (FAF) and other fundus manifestations in congenital aniridia. Methods: Fourteen patients with congenital aniridia and 14 age- and sex-matched healthy controls were examined. ...
    • Color Vision in Aniridia 

      Pedersen, Hilde Røgeberg; Hagen, Lene Aarvelta; Landsend, Erlend Christoffer Sommer; Gilson, Stuart; Utheim, Øygunn Aass; Utheim, Tor Paaske; Neitz, Maureen; Baraas, Rigmor C. (Journal article; Peer reviewed, 2018)
      Purpose: To assess color vision and its association with retinal structure in persons with congenital aniridia. Methods: We included 36 persons with congenital aniridia (10–66 years), and 52 healthy, normal trichromatic ...
    • The cone photoreceptor mosaic in aniridia: within-family phenotype-genotype discordance 

      Pedersen, Hilde Røgeberg; Neitz, Maureen; Gilson, Stuart; Landsend, Erlend Christoffer Sommer; Utheim, Øygunn Aass; Utheim, Tor Paaske; Baraas, Rigmor C. (Peer reviewed; Journal article, 2019)
      Purpose Investigate in vivo cone photoreceptor structure in familial aniridia caused by deletion in the PAX6 gene to elucidate the complexity of between-individual variation in retinal phenotype. Design Descriptive ...
    • Data Descriptor: Wide-field corneal subbasal nerve plexus mosaics in age-controlled healthy and type 2 diabetes populations 

      Lagali, Neil; Allgeier, Stephan; Guimarães, Pedro; Badian, Reza; Ruggeri, Alfredo; Köhler, Bernd; Utheim, Tor Paaske; Peebo, Beatrice; Peterson, Magnus; Dahlin, Lars B.; Rolandsson, Olov (Journal article; Peer reviewed, 2018)
      A dense nerve plexus in the clear outer window of the eye, the cornea, can be imaged in vivo to enable non-invasive monitoring of peripheral nerve degeneration in diabetes. However, a limited field of view of corneal nerves, ...
    • Dendritic cell maturation in the corneal epithelium with onset of type 2 diabetes is associated with tumor necrosis factor receptor superfamily member 9 

      Lagali, Neil; Badian, Reza; Liu, Xu; Feldreich, Tobias R.; Ärnlöv, Johan; Utheim, Tor Paaske; Dahlin, Lars B.; Rolandsson, Olov (Journal article; Peer reviewed, 2018)
      Type 2 diabetes mellitus is characterized by a low-grade inflammation; however, mechanisms leading to this inflammation in specific tissues are not well understood. The eye can be affected by diabetes; thus, we hypothesized ...
    • Diagnostic Test Efficacy of Meibomian Gland Morphology and Function 

      Xiao, Jiaxin; Adil, Muhammed Yasin; Olafsson, Jonatan; Chen, Xiangjun; Utheim, Øygunn Aass; Ræder, Sten; Lagali, Neil; Dartt, Darlene Ann; Utheim, Tor Paaske (Journal article; Peer reviewed, 2019)
      Meibomian gland dysfunction (MGD) is the leading cause of dry eye and proposed treatments are based on disease severity. Our purpose was to establish reliable morphologic measurements of meibomian glands for evaluating MGD ...
    • Effects of explant size on epithelial outgrowth, thickness, stratification, ultrastructure and phenotype of cultured limbal epithelial cells 

      Utheim, Øygunn Aass; Pasovic, Lara; Ræder, Sten; Eidet, Jon Roger; Fostad, Ida; Sehic, Amer; Roald, Borghild; de la Paz, Maria Fideliz; Lyberg, Torstein; Dartt, Darlene A.; Utheim, Tor Paaske (Journal article; Peer reviewed, 2019)
      Purpose Transplantation of limbal stem cells is a promising therapy for limbal stem cell deficiency. Limbal cells can be harvested from either a healthy part of the patient’s eye or the eye of a donor. Small explants are ...
    • Evaluation of Equivalent Keratometry Readings Obtained by Pentacam HR (High Resolution) 

      Hua, Yanjun; Zhang, Xiaolan; Utheim, Tor Paaske; Huang, Jinhai; Pan, Chao; Tan, Weina; Wang, Qinmei (Journal article; Peer reviewed, 2016)
      PURPOSE: To assess the repeatability of Equivalent Keratometry Readings (EKRs) obtained by the Pentacam HR (high resolution) in untreated and post-LASIK eyes, and to compare them with the keratometry (K) values obtained ...
    • Functional and Morphological Evaluation of Meibomian Glands in the Assessment of Meibomian Gland Dysfunction Subtype and Severity 

      Xiao, Jiaxin; Adil, Muhammed Yasin; Chen, Xiangjun; Utheim, Øygunn A.; Ræder, Sten; Tønseth, Kim Alexander; Lagali, Neil S.; Dartt, Darlene A.; Utheim, Tor Paaske (Peer reviewed; Journal article, 2019)
      Purpose To classify subtypes of meibomian gland dysfunction (MGD) and evaluate the dependency of dry eye signs, symptoms, and parameters on MGD subtype. Design Cross-sectional study. Study Population: the right eyes ...
    • Hyaluronan-Based Hydrogel Scaffolds for Limbal Stem Cell Transplantation: A Review 

      Yazdani, Mazyar; Shahdafar, Aboulghassem; Jackson, Catherine; Utheim, Tor Paaske (Peer reviewed; Journal article, 2019)
      Hyaluronan (HA), also termed hyaluronic acid or hyaluronate, is a major component of the extracellular matrix. This non-sulfated glycosaminoglycan plays a key role in cell proliferation, growth, survival, polarization, and ...
    • Meibomian gland dysfunction and keratopathy are associated with dry eye disease in aniridia 

      Landsend, Erlend Christoffer Sommer; Pedersen, Hilde Røgeberg; Utheim, Øygunn Aass; Xiao, Jiaxin; Adil, Muhammed Yasin; Tashbayev, Behzod; Lagali, Neil; Dartt, Darlene Ann; Baraas, Rigmor C.; Utheim, Tor Paaske (Journal article; Peer reviewed, 2018)
      Aims To investigate the aetiology and characteristics of dry eye disease (DED) in a Nordic cohort of patients with congenital aniridia. Methods Thirty-four Norwegian and one Danish subject with congenital aniridia and 21 ...
    • Meibomian Gland Morphology is a Sensitive Early Indicator of Meibomian Gland Dysfunction 

      Adil, Muhammed Yasin; Xiao, J; Olaffson, J.S.; Chen, Xiangjun; Lagali, Neil; Ræder, Sten; Utheim, Øygunn Aass; Dartt, Darlene A.; Utheim, Tor Paaske (Journal article; Peer reviewed, 2018)
      Purpose To investigate the relationship between meibomian gland (MG) morphology and clinical dry eye tests in patients with meibomian gland dysfunction (MGD). Design Cross-sectional study. Subjects Total 538 MGD patients ...
    • Patients with non-Sjögren's sicca report poorer general and oral health-related quality of life than patients with Sjögren's syndrome: a cross-sectional study 

      Tashbayev, Behzod; Garen, Torhild Oddveig; Palm, Øyvind; Chen, Xiangjun; Herlofson, Bente Brokstad; Young Vik, Alix Rosslyn; Hove, Lene Hystad; Rykke, Morten; Singh, Preet Bano; Aqrawi, Lara Adnan; Utheim, Øygunn Aass; Utheim, Tor Paaske; Jensen, Janicke Cecilie Liaaen (Peer reviewed; Journal article, 2020)
      Understanding the impact of the disease on quality of life is crucial in patient management. In this cross-sectional study, general and oral health-related quality of life questionnaires, and thorough examinations of oral ...
    • Tear production levels and dry eye disease severity in a large Norwegian cohort 

      Yazdani, Mazyar; Chen, Xiangjun; Tashbayev, Behzod; Utheim, Øygunn Aass; Ræder, Sten; Lagli, Neil; Stojanovic, Aleksandar; Dartt, Darlene Ann; Utheim, Tor Paaske (Journal article; Peer reviewed, 2018)
      Purpose: To determine if the Schirmer I test (without anesthesia) cut-off value is a predictor of dry eye severity in a large Norwegian cohort of dry eye disease (DED) patients, which are grouped into six levels of tear ...
    • The Glutamine Transporter Slc38a1 Regulates GABAergic Neurotransmission and Synaptic Plasticity 

      Raheel, Tayyaba Qureshi; Sørensen, Christina; Berghuis, Paul; Jensen, Vidar; Dobszay, Marton B.; Farkas, Tamas; Dalen, Knut Tomas; Guo, Caiying; Hassel, Bjørnar; Utheim, Tor Paaske; Hvalby, Øivind C; Hafting, Torkel; Harkany, Tibor; Fyhn, Marianne; Chaudhry, Farrukh Abbas (Journal article; Peer reviewed, 2019)
      GABA signaling sustains fundamental brain functions, from nervous system development to the synchronization of population activity and synaptic plasticity. Despite these pivotal features, molecular determinants underscoring ...
    • The level of inflammatory tear cytokines is elevated in congenital Aniridia and associated with meibomian gland dysfunction 

      Landsend, Erlend Christoffer Sommer; Utheim, Øygunn Aass; Pedersen, Hilde Røgeberg; Aass, Hans Christian Dalsbotten; Lagali, Neil; Dartt, Darlene Ann; Baraas, Rigmor C.; Utheim, Tor Paaske (Journal article; Peer reviewed, 2018)
      Purpose: To investigate the tear cytokine profile in congenital aniridia, and correlate cytokine levels with ophthalmologic findings. Methods: We examined 35 patients with aniridia and 21 healthy controls. Tear fluid ...
    • The Three Paralogous MicroRNA Clusters in Development and Disease - miR-17-92, miR-106a-363, and miR-106b-25 

      Khuu, Cuong; Utheim, Tor Paaske; Sehic, Amer (Journal article; Peer reviewed, 2016)
      MicroRNAs (miRNAs) form a class of noncoding RNA genes whose products are small single-stranded RNAs that are involved in the regulation of translation and degradation of mRNAs. There is a fine balance between deregulation ...
    • Tissue harvesting site and culture medium affect attachment, growth, and phenotype of ex vivo expanded oral mucosal epithelial cells 

      Islam, Rakibul; Eidet, Jon Roger; Badian, Reza; Lippestad, Marit; Messelt, Edvard Berger; Griffith, May; Dartt, Darlene Ann; Utheim, Tor Paaske (Journal article; Peer reviewed, 2017)
      Transplantation of cultured oral mucosal epithelial cells (OMECs) is a promising treatment strategy for limbal stem cell deficiency. In order to improve the culture method, we investigated the effects of four culture media ...
    • Transcriptome Analysis of Cultured Limbal Epithelial Cells on an Intact Amniotic Membrane following Hypothermic Storage in Optisol-GS 

      Utheim, Tor Paaske; Salvanos, Panagiotis; Utheim, Øygunn Aass; Ræder, Sten; Pasovic, Lara; Olstad, Ole Kristoffer; De la paz, Maria; Sehic, Amer (Journal article; Peer reviewed, 2016)
      The aim of the present study was to investigate the molecular mechanisms underlying activation of cell death pathways using genome-wide transcriptional analysis in human limbal epithelial cell (HLEC) cultures following ...