• Change in Ocular Surface Staining during Eyelid Warming Is Related to Tear Cytokine Levels 

      Landsend, Erlend Christoffer Sommer; Olafsson, Jonatan; Lai, Xiaoran; Aass, Hans Christian Dalsbotten; Utheim, Tor Paaske (Peer reviewed; Journal article, 2022)
      Purpose: To investigate the changes in the tear cytokine profile of patients with meibomian gland dysfunction (MGD) treated with eyelid warming and to correlate these changes with clinical parameters for dry eye disease ...
    • Characteristics and Utility of Fundus Autofluorescence in Congenital Aniridia Using Scanning Laser Ophthalmoscopy 

      Landsend, Erlend Christoffer Sommer; Pedersen, Hilde Røgeberg; Utheim, Øygunn Aass; Rueegg, Corina Silvia; Baraas, Rigmor C.; Lagali, Neil; Bragadottir, Ragnheidur; Moe, Morten Carsten; Utheim, Tor Paaske (Journal article; Peer reviewed, 2019)
      Purpose: To investigate fundus autofluorescence (FAF) and other fundus manifestations in congenital aniridia. Methods: Fourteen patients with congenital aniridia and 14 age- and sex-matched healthy controls were examined. ...
    • Color Vision in Aniridia 

      Pedersen, Hilde Røgeberg; Hagen, Lene Aarvelta; Landsend, Erlend Christoffer Sommer; Gilson, Stuart; Utheim, Øygunn Aass; Utheim, Tor Paaske; Neitz, Maureen; Baraas, Rigmor C. (Journal article; Peer reviewed, 2018)
      Purpose: To assess color vision and its association with retinal structure in persons with congenital aniridia. Methods: We included 36 persons with congenital aniridia (10–66 years), and 52 healthy, normal trichromatic ...
    • A comparison between hyaluronic acid and other single ingredient eye drops for dry eye, a review 

      Hynnekleiv, Leif; Magnø, Morten Schjerven; Moschowits, Emily; Tønseth, Kim Alexander; Vehof, Jelle; Utheim, Tor Paaske (Peer reviewed; Journal article, 2023)
      Dry eye disease (DED) is a highly prevalent and debilitating condition. Hyaluronic acid (HA) is a naturally occurring glycosaminoglycan that has a long history as a safe and effective DED treatment. HA is frequently used ...
    • The cone photoreceptor mosaic in aniridia: within-family phenotype-genotype discordance 

      Pedersen, Hilde Røgeberg; Neitz, Maureen; Gilson, Stuart; Landsend, Erlend Christoffer Sommer; Utheim, Øygunn Aass; Utheim, Tor Paaske; Baraas, Rigmor C. (Peer reviewed; Journal article, 2019)
      Purpose Investigate in vivo cone photoreceptor structure in familial aniridia caused by deletion in the PAX6 gene to elucidate the complexity of between-individual variation in retinal phenotype. Design Descriptive ...
    • Data Descriptor: Wide-field corneal subbasal nerve plexus mosaics in age-controlled healthy and type 2 diabetes populations 

      Lagali, Neil; Allgeier, Stephan; Guimarães, Pedro; Badian, Reza; Ruggeri, Alfredo; Köhler, Bernd; Utheim, Tor Paaske; Peebo, Beatrice; Peterson, Magnus; Dahlin, Lars B.; Rolandsson, Olov (Journal article; Peer reviewed, 2018)
      A dense nerve plexus in the clear outer window of the eye, the cornea, can be imaged in vivo to enable non-invasive monitoring of peripheral nerve degeneration in diabetes. However, a limited field of view of corneal nerves, ...
    • Dendritic cell maturation in the corneal epithelium with onset of type 2 diabetes is associated with tumor necrosis factor receptor superfamily member 9 

      Lagali, Neil; Badian, Reza; Liu, Xu; Feldreich, Tobias R.; Ärnlöv, Johan; Utheim, Tor Paaske; Dahlin, Lars B.; Rolandsson, Olov (Journal article; Peer reviewed, 2018)
      Type 2 diabetes mellitus is characterized by a low-grade inflammation; however, mechanisms leading to this inflammation in specific tissues are not well understood. The eye can be affected by diabetes; thus, we hypothesized ...
    • Diagnostic Test Efficacy of Meibomian Gland Morphology and Function 

      Xiao, Jiaxin; Adil, Muhammed Yasin; Olafsson, Jonatan; Chen, Xiangjun; Utheim, Øygunn Aass; Ræder, Sten; Lagali, Neil; Dartt, Darlene Ann; Utheim, Tor Paaske (Journal article; Peer reviewed, 2019)
      Meibomian gland dysfunction (MGD) is the leading cause of dry eye and proposed treatments are based on disease severity. Our purpose was to establish reliable morphologic measurements of meibomian glands for evaluating MGD ...
    • Effects of explant size on epithelial outgrowth, thickness, stratification, ultrastructure and phenotype of cultured limbal epithelial cells 

      Utheim, Øygunn Aass; Pasovic, Lara; Ræder, Sten; Eidet, Jon Roger; Fostad, Ida; Sehic, Amer; Roald, Borghild; de la Paz, Maria Fideliz; Lyberg, Torstein; Dartt, Darlene A.; Utheim, Tor Paaske (Journal article; Peer reviewed, 2019)
      Purpose Transplantation of limbal stem cells is a promising therapy for limbal stem cell deficiency. Limbal cells can be harvested from either a healthy part of the patient’s eye or the eye of a donor. Small explants are ...
    • Evaluation of Equivalent Keratometry Readings Obtained by Pentacam HR (High Resolution) 

      Hua, Yanjun; Zhang, Xiaolan; Utheim, Tor Paaske; Huang, Jinhai; Pan, Chao; Tan, Weina; Wang, Qinmei (Journal article; Peer reviewed, 2016)
      PURPOSE: To assess the repeatability of Equivalent Keratometry Readings (EKRs) obtained by the Pentacam HR (high resolution) in untreated and post-LASIK eyes, and to compare them with the keratometry (K) values obtained ...
    • Functional and Morphological Evaluation of Meibomian Glands in the Assessment of Meibomian Gland Dysfunction Subtype and Severity 

      Xiao, Jiaxin; Adil, Muhammed Yasin; Chen, Xiangjun; Utheim, Øygunn A.; Ræder, Sten; Tønseth, Kim Alexander; Lagali, Neil S.; Dartt, Darlene A.; Utheim, Tor Paaske (Peer reviewed; Journal article, 2019)
      Purpose To classify subtypes of meibomian gland dysfunction (MGD) and evaluate the dependency of dry eye signs, symptoms, and parameters on MGD subtype. Design Cross-sectional study. Study Population: the right eyes ...
    • Hot towels: The bedrock of Meibomian gland dysfunction treatment – A review 

      Magnø, Morten Schjerven; Olafsson, Jonatan; Beining, Marie Wangen; Moschowits, Emily; Lagali, Neil Satish; Wolffsohn, James S.; Craig, Jennifer P.; Vehof, Jelle; Dartt, Darlene Ann; Utheim, Tor Paaske (Peer reviewed; Journal article, 2022)
      Background: Meibomian gland dysfunction (MGD) reduces quality-of-life and hinders work productivity of millions of patients, with high direct and indirect societal costs. Thickened meibum obstructs the glands and disrupts ...
    • Hyaluronan-Based Hydrogel Scaffolds for Limbal Stem Cell Transplantation: A Review 

      Yazdani, Mazyar; Shahdafar, Aboulghassem; Jackson, Catherine; Utheim, Tor Paaske (Peer reviewed; Journal article, 2019)
      Hyaluronan (HA), also termed hyaluronic acid or hyaluronate, is a major component of the extracellular matrix. This non-sulfated glycosaminoglycan plays a key role in cell proliferation, growth, survival, polarization, and ...
    • Intense pulsed light treatment in meibomian gland dysfunction: Past, present, and future 

      Fineide, Fredrik; Magnø, Morten Schjerven; Khan, Ayyad Ahmad Zartasht; Chen, Xiangjun; Vehof, Jelle; Utheim, Tor Paaske (Peer reviewed; Journal article, 2023)
      Dry eye disease is a highly prevalent condition, which can substantially impair quality of life, work productivity, and vision. It is considered an inflammatory disease and the most common cause is meibomian gland dysfunction. ...
    • Meibomian gland dysfunction and keratopathy are associated with dry eye disease in aniridia 

      Landsend, Erlend Christoffer Sommer; Pedersen, Hilde Røgeberg; Utheim, Øygunn Aass; Xiao, Jiaxin; Adil, Muhammed Yasin; Tashbayev, Behzod; Lagali, Neil; Dartt, Darlene Ann; Baraas, Rigmor C.; Utheim, Tor Paaske (Journal article; Peer reviewed, 2018)
      Aims To investigate the aetiology and characteristics of dry eye disease (DED) in a Nordic cohort of patients with congenital aniridia. Methods Thirty-four Norwegian and one Danish subject with congenital aniridia and 21 ...
    • Meibomian gland dysfunction is highly prevalent among first-time visitors at a Norwegian dry eye specialist clinic 

      Badian, Reza; Utheim, Tor Paaske; Chen, Xiangjun; Utheim, Øygunn Aass; Ræder, Sten; Ystenæs, Ann Elisabeth; Aakre, Bente Monica; Sundling, Vibeke (Peer reviewed; Journal article, 2021)
      To investigate the prevalence of meibomian gland dysfunction (MGD) in patients presenting with subjective dry eye-related symptoms at their first-time consultation in a Norwegian specialized ocular surface clinic. Additionally, ...
    • Meibomian Gland Morphology is a Sensitive Early Indicator of Meibomian Gland Dysfunction 

      Adil, Muhammed Yasin; Xiao, J; Olaffson, J.S.; Chen, Xiangjun; Lagali, Neil; Ræder, Sten; Utheim, Øygunn Aass; Dartt, Darlene A.; Utheim, Tor Paaske (Journal article; Peer reviewed, 2018)
      Purpose To investigate the relationship between meibomian gland (MG) morphology and clinical dry eye tests in patients with meibomian gland dysfunction (MGD). Design Cross-sectional study. Subjects Total 538 MGD patients ...
    • Patients with non-Sjögren's sicca report poorer general and oral health-related quality of life than patients with Sjögren's syndrome: a cross-sectional study 

      Tashbayev, Behzod; Garen, Torhild Oddveig; Palm, Øyvind; Chen, Xiangjun; Herlofson, Bente Brokstad; Young Vik, Alix Rosslyn; Hove, Lene Hystad; Rykke, Morten; Singh, Preet Bano; Aqrawi, Lara Adnan; Utheim, Øygunn Aass; Utheim, Tor Paaske; Jensen, Janicke Cecilie Liaaen (Peer reviewed; Journal article, 2020)
      Understanding the impact of the disease on quality of life is crucial in patient management. In this cross-sectional study, general and oral health-related quality of life questionnaires, and thorough examinations of oral ...
    • PAX6 Genotypic and Retinal Phenotypic Characterization in Congenital Aniridia 

      Pedersen, Hilde Røgeberg; Baraas, Rigmor C.; Landsend, Erlend Christoffer Sommer; Utheim, Øygunn Aass; Utheim, Tor Paaske; Gilson, Stuart; Neitz, Maureen (Peer reviewed; Journal article, 2020)
      PURPOSE: To investigate the association between PAX6 genotype and macular morphology in congenital aniridia. METHODS: The study included 37 participants (15 males) with congenital aniridia (aged 10–72 years) and 58 ...
    • Predicting an unstable tear film through artificial intelligence 

      Fineide, Fredrik; Storås, Andrea; Chen, Xiangjun; Magnø, Morten Schjerven; Yazidi, Anis; Riegler, Michael; Utheim, Tor Paaske (Peer reviewed; Journal article, 2022)
      Dry eye disease is one of the most common ophthalmological complaints and is defined by a loss of tear film homeostasis. Establishing a diagnosis can be time-consuming, resource demanding and unpleasant for the patient. ...