Browsing USN Open Archive by Author "Sandhu, Vandana"
Now showing items 1-5 of 5
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A systems biology approach to integrated molecular analysis in pancreatic and periampullary adenocarcinoma
Sandhu, Vandana (Doctoral dissertations at the University College of Southeast Norway;2, Doctoral thesis, 2016-04-13)Pancreatic and periampullary adenocarcinoma (PA) is a highly lethal disease, for which the mortality rate closely parallels the incidence rate. Most of the PA patients remain asymptomatic until the disease reaches an ... -
Meta-Analysis of 1,200 Transcriptomic Profiles Identifies a Prognostic Model for Pancreatic Ductal Adenocarcinoma
Sandhu, Vandana; Labori, Knut Jørgen; Borgida, Ayelet; Lungu, Ilinca; Bartlett, John; Hafezi-Bakhtiari, Sara; Denroche, Robert E.; Jang, Gun Ho; Pasternack, Danielle; Mbaabali, Faridah; Watson, Matthew; Wilson, Julie; Kure, Elin H.; Gallinger, Steven; Haibe-Kains, Benjamin (Peer reviewed; Journal article, 2019)PURPOSE: With a dismal 8% median 5-year overall survival, pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy. Only 10% to 20% of patients are eligible for surgery, and more than 50% of these patients ... -
Molecular characterisation of TP53 mutated squamous cell carcinomas of the lung to identify putative targets for therapy
Haakensen, Vilde Drageset; Khadse, Anand; Sandhu, Vandana; Halvorsen, Ann Rita; Solberg, Steinar; Jørgensen, Lars Hilmar; Brustugun, Odd Terje; Kure, Elin Wenche Hegland; Helland, Åslaug (Peer reviewed; Journal article, 2020)Personalised cancer treatment depends on identification of therapeutically relevant biological subgroups of patients for assessing effect of treatment and to discover new therapeutic options. By analyses in heterogeneous ... -
Non-small cell lung cancer is characterised by a distinct inflammatory signature in serum compared with chronic obstructive pulmonary disease
Eide, Hanne Astrid; Halvorsen, Ann Rita; Sandhu, Vandana; Fåne, Anne; Berg, Janna; Haakensen, Vilde Drageset; Kure, Elin H.; Brustugun, Odd Terje; Kiserud, Cecilie E.; Kyte, Jon A; Helland, Åslaug (Journal article; Peer reviewed, 2016)Development of lung cancer is closely related to smoking in a majority of patients. Most smokers, however, do not develop lung cancer in spite of a high mutational load accumulating in the lung tissue. Here we investigate ... -
Serum cytokine profiles and metabolic tumor burden in patients with non-small cell lung cancer undergoing palliative thoracic radiation therapy
Eide, Hanne Astrid; Knudtsen, Ingerid Skjei; Sandhu, Vandana; Løndalen, Ayca; Halvorsen, Ann Rita; Abravan, Azadeh; Kure, Elin H.; Bogsrud, Trond; Brustugun, Odd Terje; Kyte, Jon A; Malinen, Eirik; Helland, Åslaug (Journal article; Peer reviewed, 2018)Purpose: Radiation therapy effectively kills cancer cells and elicits local effects in the irradiated tissue. The aim of this study was to investigate the kinetics of cytokines in the serum of patients with lung cancer ...