Browsing USN Open Archive by Author "Kure, Elin H."
Now showing items 1-14 of 14
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Association between cigarette smoking, APC mutations and the risk of developing sporadic colorectal adenomas and carcinomas
Sæbø, Mona; Skjelbred, Camilla Furu; Breistein, Rebecca; Lothe, Inger Marie Bowitz; Hagen, Per Chr.; Bock, Günther; Hansteen, Inger-Lise; Kure, Elin H. (Journal article; Peer reviewed, 2006-03-17)BACKGROUND: The association between colorectal cancer (CRC) and smoking has not been consistent. Incomplete smoking history and association to a specific subset of CRC tumors have been proposed as explanations. The adenomatous ... -
Distribution of allele frequencies for genes associated with physical activity and/or physical capacity in a homogenous Norwegian cohort- a cross-sectional study
Goleva-Fjellet, Sannija; Bjurholt, Anne Mari; Kure, Elin H.; Larsen, Inger Kristin; Støren, Øyvind; Sæbø, Mona (Journal article; Peer reviewed, 2020)Background There are large individual differences in physical activity (PA) behavior as well as trainability of physical capacity. Heritability studies have shown that genes may have as much impact on exercise participation ... -
Effects of polymorphisms in ERCC1, ASE-1 and RAI on the risk of colorectal carcinomas and adenomas: a case control study
Skjelbred, Camilla Furu; Sæbø, Mona; Nexø, Bjørn Andersen; Wallin, Håkan; Hansteen, Inger-Lise; Vogel, Ulla; Kure, Elin H. (Journal article; Peer reviewed, 2006-07-03)BACKGROUND: The risk of sporadic colorectal cancer is mainly associated with lifestyle factors and may be modulated by several genetic factors of low penetrance. Genetic variants represented by single nucleotide polymorphisms ... -
Expression of NDRG2 is down-regulated in high-risk adenomas and colorectal carcinoma
Lorentzen, Anders; Vogel, Lotte K.; Lewinsky, Rikke H.; Sæbø, Mona; Skjelbred, Camilla Furu; Godiksen, Sine; Hoff, Geir; Lothe, Inger Marie Bowitz; Ikdahl, Tone; Kure, Elin H.; Mitchelmore, Cathy (Journal article; Peer reviewed, 2007-10-12)BACKGROUND: It has recently been shown that NDRG2 mRNA is down-regulated or undetectable in several human cancers and cancer cell-lines. Although the function of NDRG2 is unknown, high NDRG2 expression correlates with ... -
GPX Pro198Leu and OGG1 Ser326Cys polymorphisms and risk of development of colorectal adenomas and colorectal cancer
Hansen, Rikke; Sæbø, Mona; Skjelbred, Camilla Furu; Nexø, Bjørn Andersen; Hagen, Per Chr.; Bock, Günther; Lothe, Inger Marie Bowitz; Johnson, Egil; Aase, Steinar; Hansteen, Inger-Lise; Vogel, Ulla; Kure, Elin H. (Journal article; Peer reviewed, 2005)Little is known about genetic risk factors for colorectal cancer. We assessed the association between polymorphisms in two genes involved in DNA repair of oxidative stress, GPX and OGG1, and risk of colorectal carcinoma ... -
Increased mRNA expression levels of ERCC1, OGG1 and RAI in colorectal adenomas and carcinomas
Sæbø, Mona; Skjelbred, Camilla Furu; Nexø, Bjørn Andersen; Wallin, Håkan; Hansteen, Inger-Lise; Vogel, Ulla; Kure, Elin H. (Journal article; Peer reviewed, 2006-08-16)BACKGROUND: The majority of colorectal cancer (CRC) cases develop through the adenoma-carcinoma pathway. If an increase in DNA repair expression is detected in both early adenomas and carcinomas it may indicate that low ... -
Meat, vegetables and genetic polymorphisms and the risk of colorectal carcinomas and adenomas
Skjelbred, Camilla Furu; Sæbø, Mona; Hjartåker, Anette; Grotmol, Tom; Hansteen, Inger-Lise; Tveit, Kjell M.; Hoff, Geir; Kure, Elin H. (Journal article; Peer reviewed, 2007-12-19)BACKGROUND: The risk of sporadic colorectal cancer (CRC) is mainly associated with lifestyle factors, particularly dietary factors. Diets high in red meat and fat and low in fruit and vegetables are associated with an ... -
Meta-Analysis of 1,200 Transcriptomic Profiles Identifies a Prognostic Model for Pancreatic Ductal Adenocarcinoma
Sandhu, Vandana; Labori, Knut Jørgen; Borgida, Ayelet; Lungu, Ilinca; Bartlett, John; Hafezi-Bakhtiari, Sara; Denroche, Robert E.; Jang, Gun Ho; Pasternack, Danielle; Mbaabali, Faridah; Watson, Matthew; Wilson, Julie; Kure, Elin H.; Gallinger, Steven; Haibe-Kains, Benjamin (Peer reviewed; Journal article, 2019)PURPOSE: With a dismal 8% median 5-year overall survival, pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy. Only 10% to 20% of patients are eligible for surgery, and more than 50% of these patients ... -
Non-small cell lung cancer is characterised by a distinct inflammatory signature in serum compared with chronic obstructive pulmonary disease
Eide, Hanne Astrid; Halvorsen, Ann Rita; Sandhu, Vandana; Fåne, Anne; Berg, Janna; Haakensen, Vilde Drageset; Kure, Elin H.; Brustugun, Odd Terje; Kiserud, Cecilie E.; Kyte, Jon A; Helland, Åslaug (Journal article; Peer reviewed, 2016)Development of lung cancer is closely related to smoking in a majority of patients. Most smokers, however, do not develop lung cancer in spite of a high mutational load accumulating in the lung tissue. Here we investigate ... -
Polymorphisms of the XRCC1, XRCC3 and XPD genes and risk of colorectal adenoma and carcinoma, in a Norwegian cohort: a case control study
Skjelbred, Camilla Furu; Sæbø, Mona; Wallin, Håkan; Nexø, Bjørn Andersen; Hagen, Per Chr.; Lothe, Inger Marie Bowitz; Aase, Steinar; Johnson, Egil; Hansteen, Inger-Lise; Vogel, Ulla; Kure, Elin H. (Journal article; Peer reviewed, 2006-03-16)BACKGROUND: Genetic polymorphisms in DNA repair genes may influence individual variation in DNA repair capacity, which may be associated with risk of developing cancer. For colorectal cancer the importance of mutations in ... -
Serum cytokine profiles and metabolic tumor burden in patients with non-small cell lung cancer undergoing palliative thoracic radiation therapy
Eide, Hanne Astrid; Knudtsen, Ingerid Skjei; Sandhu, Vandana; Løndalen, Ayca; Halvorsen, Ann Rita; Abravan, Azadeh; Kure, Elin H.; Bogsrud, Trond; Brustugun, Odd Terje; Kyte, Jon A; Malinen, Eirik; Helland, Åslaug (Journal article; Peer reviewed, 2018)Purpose: Radiation therapy effectively kills cancer cells and elicits local effects in the irradiated tissue. The aim of this study was to investigate the kinetics of cytokines in the serum of patients with lung cancer ... -
The level of claudin-7 is reduced as an early event in colorectal carcinogenesis
Bornholdt, Jette; Friis, Stine; Godiksen, Sine; Poulsen, Steen S.; Santoni-Rugiu, Eric; Bisgaard, Hanne C.; Lothe, Inger Marie Bowitz; Andersen, Tone Ikdahl; Tveit, Magne Kjell; Johnson, Egil; Kure, Elin H.; Vogel, Lotte K. (Journal article; Peer reviewed, 2011-02-10)BACKGROUND: Compromised epithelial barriers are found in dysplastic tissue of the gastrointestinal tract. Claudins are transmembrane proteins important for tight junctions. Claudins regulate the paracellular transport and ... -
The ratio of Matriptase/HAI-1 mRNA is higher in colorectal cancer adenomas and carcinomas than corresponding tissue from control individuals
Vogel, Lotte K.; Sæbø, Mona; Skjelbred, Camilla Furu; Abell, Kathrine; Pedersen, Esben D.K.; Vogel, Ulla; Kure, Elin H. (Journal article; Peer reviewed, 2006-07-04)BACKGROUND: It has recently been shown that overexpression of the serine protease, matriptase, in transgenic mice causes a dramatically increased frequency of carcinoma formation. Overexpression of HAI-1 and matriptase ... -
Total circulating cell-free DNA as a prognostic biomarker in metastatic colorectal cancer before first-line oxaliplatin-based chemotherapy
Hamfjord, Julian; Guren, Tormod Kyrre; Dajani, Olav; Johansen, Julia Sidenius; Glimelius, Bengt; Sorbye, Halfdan; Pfeiffer, Per; Lingjærde, Ole Christian; Tveit, Magne Kjell; Kure, Elin H.; Pallisgaard, Niels; Spindler, Karen-Lise Garm (Journal article; Peer reviewed, 2019)Background Metastatic colorectal cancer (mCRC) is a heterogeneous disease where prognosis is dependent both on tumor biology and host factors. Total circulating cell-free DNA (cfDNA) has shown to harbor prognostic ...