Now showing items 21-32 of 32

    • Role of stem cells in regenerative treatment of dry eye disease caused by lacrimal gland dysfunction 

      Jackson, Catherine Joan; Naqvi, Maria; Gundersen, Kjell Gunnar; Utheim, Tor Paaske (Peer reviewed; Journal article, 2022)
      An ageing population and increased screen use in younger people have contributed to a rise in incidence of dry eye disease (DED). Quality of life can be significantly affected by DED, with patients experiencing eye dryness, ...
    • Stem cell function is conserved during shortterm storage of cultured epidermal cell sheets at 12°C 

      Ringstad, Håkon; Reppe, Sjur; Schøyen, Tine Hiorth; Tønseth, Kim Alexander; Utheim, Tor Paaske; Jackson, Catherine (Peer reviewed; Journal article, 2020)
      Transplantation of cultured epidermal cell sheets (CES) can be life-saving for patients with large area burns. CES have also been successfully used to regenerate eye and urethral epithelia in animal models. Short-term ...
    • Tear production levels and dry eye disease severity in a large Norwegian cohort 

      Yazdani, Mazyar; Chen, Xiangjun; Tashbayev, Behzod; Utheim, Øygunn Aass; Ræder, Sten; Lagli, Neil; Stojanovic, Aleksandar; Dartt, Darlene Ann; Utheim, Tor Paaske (Journal article; Peer reviewed, 2018)
      Purpose: To determine if the Schirmer I test (without anesthesia) cut-off value is a predictor of dry eye severity in a large Norwegian cohort of dry eye disease (DED) patients, which are grouped into six levels of tear ...
    • The Glutamine Transporter Slc38a1 Regulates GABAergic Neurotransmission and Synaptic Plasticity 

      Raheel, Tayyaba Qureshi; Sørensen, Christina; Berghuis, Paul; Jensen, Vidar; Dobszay, Marton B.; Farkas, Tamas; Dalen, Knut Tomas; Guo, Caiying; Hassel, Bjørnar; Utheim, Tor Paaske; Hvalby, Øivind C; Hafting, Torkel; Harkany, Tibor; Fyhn, Marianne; Chaudhry, Farrukh Abbas (Journal article; Peer reviewed, 2019)
      GABA signaling sustains fundamental brain functions, from nervous system development to the synchronization of population activity and synaptic plasticity. Despite these pivotal features, molecular determinants underscoring ...
    • The level of inflammatory tear cytokines is elevated in congenital Aniridia and associated with meibomian gland dysfunction 

      Landsend, Erlend Christoffer Sommer; Utheim, Øygunn Aass; Pedersen, Hilde Røgeberg; Aass, Hans Christian Dalsbotten; Lagali, Neil; Dartt, Darlene Ann; Baraas, Rigmor C.; Utheim, Tor Paaske (Journal article; Peer reviewed, 2018)
      Purpose: To investigate the tear cytokine profile in congenital aniridia, and correlate cytokine levels with ophthalmologic findings. Methods: We examined 35 patients with aniridia and 21 healthy controls. Tear fluid ...
    • The Three Paralogous MicroRNA Clusters in Development and Disease - miR-17-92, miR-106a-363, and miR-106b-25 

      Khuu, Cuong; Utheim, Tor Paaske; Sehic, Amer (Journal article; Peer reviewed, 2016)
      MicroRNAs (miRNAs) form a class of noncoding RNA genes whose products are small single-stranded RNAs that are involved in the regulation of translation and degradation of mRNAs. There is a fine balance between deregulation ...
    • TheraPearl Eye Mask and Blephasteam for the treatment of meibomian gland dysfunction: a randomized, comparative clinical trial 

      Olafsson, Jonatan; Lai, Xiaoran; Landsend, Erlend Christoffer Sommer; Olafsson, Snorri; Parissi, Eric; Utheim, Øygunn Aass; Ræder, Sten; Badian, Reza; Lagali, Neil Satish; Dartt, Darlene A.; Utheim, Tor Paaske (Journal article; Peer reviewed, 2021)
      Meibomian gland dysfunction (MGD) is the most common cause of dry eye disease (DED). In this study, we aimed to compare the effects of eyelid warming treatment using either TheraPearl Eye Mask (Bausch & Lomb Inc., New York, ...
    • Tissue harvesting site and culture medium affect attachment, growth, and phenotype of ex vivo expanded oral mucosal epithelial cells 

      Islam, Rakibul; Eidet, Jon Roger; Badian, Reza; Lippestad, Marit; Messelt, Edvard Berger; Griffith, May; Dartt, Darlene Ann; Utheim, Tor Paaske (Journal article; Peer reviewed, 2017)
      Transplantation of cultured oral mucosal epithelial cells (OMECs) is a promising treatment strategy for limbal stem cell deficiency. In order to improve the culture method, we investigated the effects of four culture media ...
    • Topical glaucoma medications – Clinical implications for the ocular surface 

      Fineide, Fredrik; Lagali, Neil Satish; Adil, Muhammed Yasin; Arita, Reiko; Kolko, Miriam; Vehof, Jelle; Utheim, Tor Paaske (Peer reviewed; Journal article, 2022)
      Glaucoma is a leading cause of irreversible blindness. The use of topical eye drops to reduce intraocular pressure remains the mainstay treatment. These eye drops frequently contain preservatives designed to ensure sterility ...
    • Transcriptome Analysis of Cultured Limbal Epithelial Cells on an Intact Amniotic Membrane following Hypothermic Storage in Optisol-GS 

      Utheim, Tor Paaske; Salvanos, Panagiotis; Utheim, Øygunn Aass; Ræder, Sten; Pasovic, Lara; Olstad, Ole Kristoffer; De la paz, Maria; Sehic, Amer (Journal article; Peer reviewed, 2016)
      The aim of the present study was to investigate the molecular mechanisms underlying activation of cell death pathways using genome-wide transcriptional analysis in human limbal epithelial cell (HLEC) cultures following ...
    • Utility of Tear Osmolarity Measurement in Diagnosis of Dry Eye Disease 

      Tashbayev, Behzod; Utheim, Tor Paaske; Utheim, Øygunn Aass; Ræder, Sten; Jensen, Janicke Cecilie Liaaen; Yazdani, Mazyar; Lagali, Neil Satish; Vitelli, Valeria; Dartt, Darlene Ann; Chen, Xiangjun (Peer reviewed; Journal article, 2020)
      The prevalence of dry eye disease is high worldwide and poses a great burden on patients’ daily lives. Accurate diagnosis of the disease is important, and it requires application of various methods. Hyperosmolarity is ...
    • Video display terminal use and dry eye: preventive measures and future perspectives 

      Kamøy, Bjørnar; Magnø, Morten Scherven; Tellefsen Nøland, Sara Julie Maria; Moe, Morten Carsten; Petrovski, Goran; Vehof, Jelle; Utheim, Tor Paaske (Peer reviewed; Journal article, 2022)
      Background: Dry eye disease (DED) is a common cause of ocular pain and discomfort. Dry eye disease (DED) stems from a loss-of-tear film homeostasis and is frequently seen in video display terminal (VDT) users. Video display ...