7 Sykehuset Telemark: Nye registreringer
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Increased mRNA expression levels of ERCC1, OGG1 and RAI in colorectal adenomas and carcinomas
(Journal article; Peer reviewed, 2006-08-16)BACKGROUND: The majority of colorectal cancer (CRC) cases develop through the adenoma-carcinoma pathway. If an increase in DNA repair expression is detected in both early adenomas and carcinomas it may indicate that low ... -
Polymorphisms of the XRCC1, XRCC3 and XPD genes and risk of colorectal adenoma and carcinoma, in a Norwegian cohort: a case control study
(Journal article; Peer reviewed, 2006-03-16)BACKGROUND: Genetic polymorphisms in DNA repair genes may influence individual variation in DNA repair capacity, which may be associated with risk of developing cancer. For colorectal cancer the importance of mutations in ... -
Re: Baseline findings of the Italian multicenter randomized controlled trial of "once-only sigmoidoscopy"--SCORE
(Journal article; Peer reviewed, 2003) -
GPX Pro198Leu and OGG1 Ser326Cys polymorphisms and risk of development of colorectal adenomas and colorectal cancer
(Journal article; Peer reviewed, 2005)Little is known about genetic risk factors for colorectal cancer. We assessed the association between polymorphisms in two genes involved in DNA repair of oxidative stress, GPX and OGG1, and risk of colorectal carcinoma ... -
Testing for faecal calprotectin (PhiCal) in the Norwegian Colorectal Cancer Prevention trial on flexible sigmoidoscopy screening: comparison with an immunochemical test for occult blood (FlexSure OBT)
(Journal article; Peer reviewed, 2004)BACKGROUND: Screening for colorectal cancer (CRC) using guaiac based faecal occult blood tests (FOBT) has an estimated programme sensitivity of >60% but <30% for strictly asymptomatic CRC in a single screening round. In ... -
Quality control in colorectal cancer screening: systematic microbiological investigation of endoscopes used in the NORCCAP (Norwegian Colorectal Cancer Prevention) trial
(Journal article; Peer reviewed, 2003-06-13)BACKGROUND: Endoscopic colorectal cancer (CRC) screening is currently implemented in many countries. Since endoscopes cannot be sterilised, the transmission of infectious agents through endoscopes has been a matter of ... -
CRC screening: review of the evidence and suggestions on when and how to move on from randomized trials to screening programmes
(Journal article; Peer reviewed, 2004) -
The ratio of Matriptase/HAI-1 mRNA is higher in colorectal cancer adenomas and carcinomas than corresponding tissue from control individuals
(Journal article; Peer reviewed, 2006-07-04)BACKGROUND: It has recently been shown that overexpression of the serine protease, matriptase, in transgenic mice causes a dramatically increased frequency of carcinoma formation. Overexpression of HAI-1 and matriptase ... -
Association between cigarette smoking, APC mutations and the risk of developing sporadic colorectal adenomas and carcinomas
(Journal article; Peer reviewed, 2006-03-17)BACKGROUND: The association between colorectal cancer (CRC) and smoking has not been consistent. Incomplete smoking history and association to a specific subset of CRC tumors have been proposed as explanations. The adenomatous ... -
Air and carbon dioxide volumes insufflated during colonoscopy
(Journal article; Peer reviewed, 2003)BACKGROUND: During colonoscopy, air or carbon dioxide is insufflated to secure adequate visualization of the colon, and endoscopy trainees are reminded to use as little gas as possible to avoid patient discomfort. However, ... -
Screening for colorectal cancer
(Journal article; Peer reviewed, 2005)Colorectal cancer (CRC) is the most common cancer in the Nordic countries after breast and prostate cancer. About 15 000 new cancers are diagnosed and more than 7 000 patients will die from CRC in 2005. CRC fulfils most ... -
Impact of a colonoscopic screening examination for colorectal cancer on later utilization of distal GI endoscopies
(Journal article; Peer reviewed, 2006)Background: Colonoscopic screening for colorectal cancer is being implemented in an increasing number of countries. This might lead to a demand for colonoscopies that could outstrip supply. Objective: We wanted to investigate ... -
The science and politics of colorectal cancer screening
(Journal article; Peer reviewed, 2006) -
Lifestyle as a predictor for colonic neoplasia in asymptomatic individuals
(Journal article; Peer reviewed, 2006-01-13)BACKGROUND: Lifestyle is a well-established risk factor for colorectal cancer (CRC) and is also found to be associated with occurrence of adenomas. In the present study we evaluated risk factors for both low-risk adenomas ...